Got a desync, first about 55 beats into the game (if my memory serves correct) on the first Coop mission.
Additional info is that my friend didn't see the cutscene playing, and i did. After the initial desync it didn't go away even after the cutscene ended, so we just stopped after a minute or so.
Also, mission 2 and 3 worked just fine and we've played through them no problem, so it's just the 1st mission being problematic.